Dr. Shade’s Bitters No. 9

The proprietary bitters combination of Dr. Shade’s Bitters No. 9 includes dandelion, milk thistle, solidago (goldenrod), gentian, burdock, and essential oils of sweet orange, myrrh, juniper, and clove, which are delivered along with phospholipids that comprise the liposomes in which these herbs are carried. The combination of these herbs is thoughtfully selected to support the gastrointestinal tract, liver, and kidneys in their necessary functions for health and detoxification. Just a small snippet of the vast amounts of research on these herbs is highlighted below.

23 item(s)

Dr. Shade’s Bitters No. 9
1.7 fl. oz. (50 mL), Precision Pump-Top

NPN 80080302

The proprietary bitters combination of Dr. Shade’s Bitters No. 9 includes dandelion, milk thistle, solidago (goldenrod), gentian, burdock, and essential oils of sweet orange, myrrh, juniper, and clove, which are delivered along with phospholipids that comprise the liposomes in which these herbs are carried. The combination of these herbs is thoughtfully selected to support the gastrointestinal tract, liver, and kidneys in their necessary functions for health and detoxification. Just a small snippet of the vast amounts of research on these herbs is highlighted below.

Suggested Use: Take 2 to 4 pumps by mouth three
times daily. Hold in mouth 30 seconds before swallowing.
Repeat to desired dosage or as directed by healthcare
professional. Take on empty stomach, at least 10 minutes
before meals. May be stirred into small amount of water.
May take 2-4 pumps in sparkling water as needed for
digestive comfort.* Use within 60 days of opening.
If pregnant, consult physician before use.

Bitters: Balancing Agents for the Gut, and Support for Liver/Kidney Detoxification

Bitters: Balancing Agents for the Gut, and Support for Liver/Kidney Detoxification



Dandelion is known for its action on the liver and gallbladder, but also acts as an antioxidant and anti-inflammatory, and may have cholesterol lowering effects.[11],[12],[13] In animal models, supplementation with dandelion leaf extract has been shown to alleviate hepatic inflammation associated with a high-fat diet, and protect the liver from alcohol-induced oxidative stress.[14],[15] In the setting of alcohol injury, supplementation with dandelion root extract was observed to increase hepatic antioxidant activity, including glutathione (GSH), GSH-S-transferase, GSH reductase, and GSH peroxidase.

Milk thistle

Milk thistle has been vastly studied for its antioxidative, anti-inflammatory, and hepatoprotective effects in settings including acetaminophen, radiation, iron overload, alcohol and Amanita phalloides (also known as “death cap” mushroom) induced liver damage.[16] Silymarin is the active complex extracted from the seeds of the plant, with the flavonolignan silybin being the most biologically active moiety comprising 50% to 70% of silymarin. Silybin has been observed to inhibit human intestinal β-glucuronidase, blocking the release and

reabsorption of free xenobiotics and their metabolites from their glucuronide conjugates.[17] Silymarin acts as an antioxidant, enhancing hepatic and intestinal GSH levels, and stabilizing membranes by inhibiting membrane peroxidation.[18],[19]


Solidago, commonly known as goldenrod, is known for its action on the urinary tract, and is classically used for infections, inflammation, and prevention of kidney stones.[20] Solidago is rich in compounds including flavonoids, phenolic acids, sesquiterpenes, diterpenes, saponins, and several caffeoylquinic acids.[21],[22] Solidago acts as an anti-inflammatory, antimicrobial, diuretic, antispasmodic, and analgesic due to these many compounds found within it.[23] Research has also shown that the flavonoids from solidago have an activating effect on GSH-S-transferases, a critical enzyme in phase II detoxification, in a dose-dependent fashion.[24]


Gentian is one of the strongest herbal bitters most often utilized in digestive bitter formulations. Gentian is a digestive toner and modulator of stomach acid secretion, improving function in a state of deficiency but also having a protective effect on conditions such as gastritis or gastric ulcers possibly through prostaglandin pathways.[25] Gentian also acts beyond the digestive system, as the compounds in it exhibit hypoglycemic, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, immunomodulatory, and adaptogenic properties.[26],[27] As a liver protective agent, gentian has been observed to increase levels of reduced GSH, catalase, superoxide dismutase and GSH peroxidase in various settings of toxin-induced oxidative damage.[28],[29],[30]


Burdock root is commonly utilized in digestive and metabolic balancing formulas, with hypoglycemic, antioxidant, anti-inflammatory, hepatoprotective, and antimicrobial actions.[31] Burdock root has been observed to reverse decreases in GSH and increases in malondialdehyde (a marker of oxidative stress) induced by toxin exposure.[32] Caffeoylquinic acid derivatives from burdock root have been observed to have a strong antioxidant effect, greater than that of α-tocopherol.[33] Burdock extract has been shown to inhibit lipoprotein oxidation while increasing GSH, GSH reductase, GSH peroxidase, GSH-S-transferase and catalase levels.[34]

Essential oils of sweet orange, myrrh, juniper, and clove

Each of these oils contains many active compounds, a sense of which we only begin to have from the aromatic expression of its essence. Sweet orange essential oil is derived from the outer peel of the orange, which anyone who has tasted is familiar with its bitter nature. Sweet orange essential oil has been observed to have antibacterial, antifungal, and antioxidant effects.[35],[36] Myrrh has a long history of medicinal use, and is perhaps most recognized for its antimicrobial effects.[37],[38] Additionally, myrrh has been used as an anesthetic, anti-inflammatory, antioxidant, and cholesterol lowering agent.[39]

Juniper essential oil also has been shown to have broad antimicrobial action, with traditional use as an antiseptic, antidiarrheal, anti-inflammatory, and astringent, with an affinity for the urinary tract. [40],[41] Juniper also acts as an antioxidant, with metal chelating, free radical, superoxide anion radical, and hydrogen per

oxide scavenging activities.[42],[43] Finally, clove essential oil also has antimicrobial, antiviral, antiulcer, anti-inflammatory and antioxidant properties.[44],[45] As an antioxidant it has a
significant inhibitory effect against hydroxyl radicals and forms complexes with reduced metals.[46],[47],[48]

Author, Dr. Carrie Decker

Dr. Decker is a certified Naturopathic Doctor, graduating with honors from the National College of Natural Medicine (now the National University of Natural Medicine) in Portland, Oregon. Dr. Decker also has graduate degrees in biomedical and mechanical engineering from the University of Wisconsin-Madison and University of Illinois at Urbana-Champaign respectfully. Dr. Decker sees patients at her office in Portland, OR, as well as remotely, with a focus on gastrointestinal disease, mood imbalances, eating disorders, autoimmune disease, chronic fatigue, and skin conditions. Dr. Decker also supports integrative medicine education as a writer and a contributor to various resources.

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